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Resident chemist and explosives expert for the elite among the Decepticons, Mixmaster has spent his entire life learning all there is to know about chemical interaction. He can make thousands of poisons, explosives, and deadly gases from the materials around him. The other Decepticons rely on him to fashion powerful warheads for their missiles and dangerous venom in which to coat their blades.
Revenge of the Fallen film
At one point, he, Skipjack, Long Haul, Ravage, and Scrapmetal dive into Laurentian Abyss to locate Megatron's corpse. After killing Scrapmetal, they succeed in reactivating their fallen leader with the help of the Doctor.
Later, he stands atop Brooklyn bridge, and knocks down one of the U.S. flag poles, in a show of dominance.
During the battle in Egypt, a decepticon with the same body type as Mixmaster's met up with the other Constructicons to form Devastator. Meanwhile, the real Mixmaster was attacking N.E.S.T forces. After a tank shot off one of his shields, Mixmaster transformed into Cannon Mode and destroyed the tank. Jetfire arrives however, and Mixmaster couldn't hold him off. He attempted to shoot him, but Jetfire killed him by slicing him in half, and kicking his head off.