The name Omega Sentinel may refer to:
- 2002 — The Omega Sentinels, guardian robots from the Dreamwave comics portion of the Generation One continuity family.
- 2009 — Omega Sentinels, the Autobot Weapon of Mass Destruction production run from Transformers Animated.
"Omega Sentinel" should not be confused with
- Other names containing "Omega"
- Other names containing "Sentinel"