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The name Sentinel Prime could refer to:
- Sentinel Prime, the Autobot leader who preceded Optimus Prime in several different Generation One continuities.
- Sentinel Prime, an overconfident and rude member of the Autobot Elite Guard in the Transformers Animated continuity.
- Sentinel Prime, Optimus Prime's predecessor as leader of the Autobots in Dark of the Moon from the movie continuity.
Sentinel Prime should not be confused with:
- Other uses of the word Sentinel.
- Other uses of the word Prime.